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前交叉韧带 1

左旋聚乳酸等离子体处理 1

干细胞 1

纤连蛋白 1

韧带 1

黏附性 1

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Prevention of laryngeal webs through endoscopic keel placement for bilateral vocal cord lesions

null

《医学前沿（英文）》 2018年 第12卷 第3期   页码 301-306 doi: 10.1007/s11684-017-0549-0

摘要：

Transoral microresection for treatment of vocal cord lesions involving the anterior commissure may result in anterior glottic webs. In this study, we retrospectively reviewed 54 patients who underwent microsurgery for bilateral lesions involving the anterior commissure and categorized them into two groups. The keel placement and control groups received endoscopic keel placement and mitomycin C, respectively. During the follow-up of at least 1 year, the laryngeal web formation rate significantly decreased in the keel placement group compared with that in the control group (18.6% versus 54.5%, <0.05). Furthermore, the voice handicap index-10 scores for patients without web formation decreased in both the keel placement and control groups ( <0.0001 and <0.001, respectively). A pseudomembrane covering the vocal cords was detected in 16.3% (7 of 43) cases after keel removal. A total of 100% (7 of 7) of these cases and 2.8% (1 of 36) of the other cases formed laryngeal webs ( <0.0001). Endoscopic keel placement could be an effective method for preventing anterior glottic webs after surgery for bilateral vocal cord diseases involving the anterior commissure. The pseudomembrane observed at the time of keel removal may imply a high risk of web formation.

关键词： glottic stenosis     glottic web     laryngeal keel     silastic sheets     anterior commissure    

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Sensory innervation of the anterior eye segment in rats: a retrograde tracing study

Haixia LIU MD , Zhiwang LI MD , Min YANG MD , Xiang TIAN MS , Chaoying LI PhD , Lei PEI PhD ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 352-356 doi: 10.1007/s11684-009-0065-y

摘要： This study aimed to investigate the sensory innervation of the anterior eye segment in rats by retrograde tracing with 1,1-dioleyl-3,3,3,3-tetrameth-ylindocarbocyanine, 4-chlorobenesulfonate (FAST Dil) injected into the anterior chamber. In our study, the sensory innervation of distinct elements of the anterior segment of the rat’s eye, i.e. the cornea, ciliary body, iris, and trabecular meshwork, were studied by retrograde tracing using FAST Dil as a tracer. FAST Dil was injected into the anterior chambers of the rat’s eyes. The animals were sacrificed at different time points, i.e., 2, 3, 4, and 5 days after the injection. FAST Dil localization in trigeminal ganglions was studied with a fluorescent microscope. Two days after FAST Dil injection into the anterior chambers, the cornea, the ciliary body, the iris, and the trabecular meshwork were heavily labeled. Neurons in the ipsilateral trigeminal ganglion were also consistently labeled. The number of labeled cells increased over time until 4 days after FAST Dil injection. FAST Dil-labeled neurons could be divided into two parts. Most of the Dil-labeled neurons were concentrated in a sharp, longitudinal, spindle-like stripe, located in the dorso-medial side of the trigeminal ganglion, approximately two thirds of the dorsal portion. The other part of Dil-labeled neurons scattered laterally to the stripe, but just in one third of the dorsal region. Thus, with our preliminary results, we conclude that the primary afferent sensory neurons innervating the rat’s anterior eye segments aggregate in the dorso-medial part of the ipsilateral trigeminal ganglion. It is feasible to identify them using retrograde tracing with FAST Dil anterior chamber injection.

关键词： trigeminal ganglion     retrograde tracing    

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Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 408-414 doi: 10.1007/s11684-009-0069-7

摘要： Bone remodeling in orthodontic treatment has been one of the most concerned issues. The purpose of this study was to characterize the changes in bone remodeling on both labial and lingual aspects of the anterior teeth during treatment and retention. Data of 55 extraction cases (41 females and 14 males) were collected at pretreatment, post-treatment, and follow-up stages. Bone thickness on both labial and lingual aspects of the upper and lower incisors were measured at the level of the center of resistance (UC and LC) and that of 3mm apical to the upper and lower incisors’ center of resistance (UAC and LAC). For LC, with the significant lingual movement of point LIR (center of resistance of lower incisor; <0.001), no statistically significant changes in alveolar width on the labial aspect were detected, whereas the reduction of lingual alveolar width was statistically significant (<0.001). In retention, no significant movement of point LIR appeared to occur, while an increase in alveolar width on the lingual aspect was found at this stage. For LAC, the changes in alveolar width as well as the displacement of point LIA (apex of lower incisor) were similar to those of LC. On the maxilla, with the control lingual tipping movement of upper incisor, most of the anterior alveolar changes surrounding the upper incisor were analogous to those of lower incisor. But differently, during treatment, labial bone thickness was increased significantly as the upper incisor moved lingually, and in retention, no statistically significant changes were found on both labial and lingual bone thickness as the upper incisor labially proclined. It was concluded that, with lingual movement of the incisors, bone apposition on the lingual aspect may lag behind the incisor movement. In retention, the lower incisors are in a stable position, with sequential bone apposition being presented on the lingual aspect. However, the upper incisors turn out to be labially relapsed along with the lingual bone resorption and labial bone apposition occurring simultaneously.

关键词： alveolus     remodeling     orthodontics     extraction    

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Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 71-76 doi: 10.1007/s11684-010-0006-9

摘要： The recent development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing left ventricular (LV) torsion. This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patients with anterior wall myocardial infarction (AMI). A total of 55 AMI patients were divided into two groups according to their ejection fraction (EF) values (group A: LVEF≥50%; group B: LVEF<50%), and 35 normal people served as the control group. Using 2-dimensional strain software, global and regional LV rotation and displacement were obtained at two planes. Compared with the control group, patients of group A showed reduced peak LV twist of the anterior and anterior-septal wall (9.26±1.89 10.74±2.67; 9.71±1.71 11.36±2.29, both <0.05), but the radial displacement and global twist were maintained (>0.05). Differently, regional and global LV twist and radial displacement in patients of group B deceased significantly, especially in the anterior and anterior-septal wall, as compared with patients in the control or group A (both <0.05). Moreover, a strong correlation was noted between peak twist and radial displacement; the twist-displacement loop was markedly distorted in patients of group B. This study demonstrated that 2D strain has a potential ability for quantification of left ventricular global and segment twist and radial displacement in patients with coronary artery disease.

关键词： echocardiography     twist     two-dimensional strain imaging     coronary artery disease    

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增强生物工程化的前交叉韧带基质的表面特性用于即时干细胞治疗 Article

Xiaohua Yu, Paulos Y. Mengsteab, Ganesh Narayanan, Lakshmi S. Nair, Cato T. Laurencin

《工程（英文）》 2021年 第7卷 第2期   页码 153-161 doi: 10.1016/j.eng.2020.02.010

摘要：

我们之前已经研发了一种生物工程化的左旋聚乳酸（PLLA）前交叉韧带（ACL）基质，该基质在植入兔模型之前被接种了原代ACL细胞，表现出比基质单独作用时更强的愈合能力。这表明改善细胞在基质上的黏附性可能有益于生物工程化的ACL基质的愈合反应和长期性能。一种与即时诊疗干细胞疗法相结合的再生工程方法是，增强基质的表面特性来支持细胞黏附和生长。在本文中，我们研究了通过纤连蛋白的物理吸附和空气等离子体处理来增强PLLA编织超细纤维基质的细胞黏附性能。我们在三个时间点和三个纤连蛋白浓度下评估了纤连蛋白在基质上的动力学和结合效率。在25 μg·mL–1纤连蛋白溶液中孵育120 min，可实现基质的最大结合效率和细胞黏附性。在纤连蛋白吸附之前将基质置于空气等离子体中处理5 min，可显著增强接种24 h后兔骨髓间充质干细胞（R-BMMSC）的黏附性。最后，监测细胞增殖长达21 d，将基质用空气等离子体处理后，发现纤连蛋白的吸附性导致细胞数量增加。这些发现表明，空气等离子体处理和纤连蛋白吸附可以增强PLLA编织超细纤维基质的细胞黏附性，可改善基质在即时诊疗干细胞疗法中的临床疗效。

关键词： 前交叉韧带     韧带     左旋聚乳酸等离子体处理     纤连蛋白     干细胞     黏附性    

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Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

《医学前沿（英文）》 2009年 第3卷 第1期   页码 45-48 doi: 10.1007/s11684-009-0019-4

摘要： This study was aimed to explore the anterior cervical surgery methods to treat central cord syndrome without radiographic spinal fracture-dislocation (CCSWORFD), retrospectively analyze the cases of CCSWORFD, and evaluate the curative effect of anterior cervical surgery methods for CCSWORFD. Twenty four cases of CCSWORFD (19 males and 5 females), all suffering from cervical hyperextension injury, between 45-68 (average 59) years old, were operated on by anterior cervical surgery methods. Among these, 18 cases had been followed up for 6-24 (average 15) months; 18 cases, who had anterior decompression and plate fixation with titanium mesh bone grafting or iliac bone grafting achieved reliable effects based on the Japanese Orthopedics Association (JOA) evaluation (improved scores of cases with titanium mesh bone grafting, = 2.800, <0.05; improved scores of cases with iliac bone grafting, = 3.270, <0.05), and reliable reconstruction of cervical spine. The two groups obtained the same curative effect ( = 0.470, >0.05) Most of these cases had degeneration of cervical vertebra. The decompression which relieves the oppression to the spinal cord can help lessen edema of the spinal cord, and early fixation for stability of cervical vertebra is better for the recovery of spinal cord injury. Anterior operation with titanium mesh bone grafting or iliac bone grafting are both reliable curative methods for CCSWORFD, and titanium mesh bone grafting can avoid the trauma of the supplying graft. Mesh bone grafting can also shorten hospital stay.

关键词： central cord syndrome     decompression     surgical     titanium mesh    

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P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

《医学前沿（英文）》 2007年 第1卷 第4期   页码 429-432 doi: 10.1007/s11684-007-0084-5

摘要： The aim of this research was to investigate the variations of P50 auditory sensory gating (P50) in normal healthy adults and the first onset schizophrenics. By using the American Nicolet Bravo electromyography/evoked potential (EMG/EP) system, P50 was measured with conditioning-testing paradigm (paired-click stimuli S1 and S2 were used) in 58 first onset schizophrenics and 108 healthy adults, and the Positive and Negative Syndrome Scale (PANSS) was applied. The following three conclusions have been reached. (1) In normal control (NC) group, measured from central, anterior and posterior zone (Cz, Fz and Pz respectively), there were no statistical differences (>0.05) between S1 and S2 evoked P50 peak latencies (S1-P50 and S2-P50); the amplitudes of S2-P50 [(2.2±1.4), (2.3±1.5) and (2.1±1.4) μV respectively] reduced significantly as compared with S1-P50 [(5.6±3.3), (5.6±3.9) and (4.9±2.8) μV respectively] (<0.01); the S2/S1 ration, S1-S2 difference, and 100 (1-S2/S1) had no statistical differences (>0.05). (2) Compared with NC, the schizophrenic group significantly showed lower S1-P50 amplitudes (<0.01, except at Pz in which = 2.030, = 0.042), higher S2-P50 amplitudes, higher S2/S1 ratio, lower S1-S2 difference, and more decreased 100 (1-S2/S1) (<0.01) at Cz, Fz and Pz. (3) No significant correlations were found among S2/S1 ratio, S1-S2, 100 (1-S2/S1) of sensory gating and PANSS (>0.05) in schizophrenic group. The first onset schizophrenics had sensory gating deficits, which could be quantified by P50.

关键词： anterior     Positive     S2-P50     schizophrenic     EMG/EP    

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Analysis of spinal lumbar interbody fusion cage subsidence using Taguchi method, finite element analysis, and artificial neural network

Christopher John NASSAU, N. Scott LITOFSKY, Yuyi LIN

《机械工程前沿（英文）》 2012年 第7卷 第3期   页码 247-255 doi: 10.1007/s11465-012-0335-2

摘要：

Subsidence, when implant penetration induces failure of the vertebral body, occurs commonly after spinal reconstruction. Anterior lumbar interbody fusion (ALIF) cages may subside into the vertebral body and lead to kyphotic deformity. No previous studies have utilized an artificial neural network (ANN) for the design of a spinal interbody fusion cage. In this study, the neural network was applied after initiation from a Taguchi L18 orthogonal design array. Three-dimensional finite element analysis (FEA) was performed to address the resistance to subsidence based on the design changes of the material and cage contact region, including design of the ridges and size of the graft area. The calculated subsidence is derived from the ANN objective function which is defined as the resulting maximum von Mises stress (VMS) on the surface of a simulated bone body after axial compressive loading. The ANN was found to have minimized the bone surface VMS, thereby optimizing the ALIF cage given the design space. Therefore, the Taguchi-FEA-ANN approach can serve as an effective procedure for designing a spinal fusion cage and improving the biomechanical properties.

关键词： anterior lumbar interbody fusion (ALIF)     artificial neural network (ANN)     finite element     interbody cage     lumbar interbody fusion     subsidence     taguchi method    

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标题 作者 时间 类型 操作

Prevention of laryngeal webs through endoscopic keel placement for bilateral vocal cord lesions

null

期刊论文

Sensory innervation of the anterior eye segment in rats: a retrograde tracing study

Haixia LIU MD , Zhiwang LI MD , Min YANG MD , Xiang TIAN MS , Chaoying LI PhD , Lei PEI PhD ,

期刊论文

Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

期刊论文

Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

期刊论文

增强生物工程化的前交叉韧带基质的表面特性用于即时干细胞治疗

Xiaohua Yu, Paulos Y. Mengsteab, Ganesh Narayanan, Lakshmi S. Nair, Cato T. Laurencin

期刊论文

Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

期刊论文

P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

期刊论文

Analysis of spinal lumbar interbody fusion cage subsidence using Taguchi method, finite element analysis, and artificial neural network

Christopher John NASSAU, N. Scott LITOFSKY, Yuyi LIN

期刊论文